ATAC-seq

Multi-omics analyses identify transcription factor interplay in corneal epithelial fate determination and disease

The homeostasis of the transparent corneal epithelium in the eye is maintained by limbal stem cells with proper cell fates. A potential disease mechanism underlying corneal opacity has been proposed to be limbal stem cells acquiring characteristics of keratinocytes of the non-transparent epidermis. We performed a multi-omics analysis of human limbal stem cells derived from the cornea and keratinocytes from the epidermis, and characterized their similar yet distinct molecular signatures.

Smits JGA, Cunha D, Qu J, Nicholas Owen, Latta L, Szentmary N, Seitz B, Roux L, Moosajee M, Aberdam D, van Heeringen SJ, Zhou H