Epigenetics

Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina
The crumbs cell polarity complex plays a crucial role in apical-basal epithelial polarity, cellular adhesion, and morphogenesis. Homozygous variants in human CRB1 result in autosomal recessive Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP), with no established genotype-phenotype correlation. We performed integrative transcriptomic and methylomic analysis of whole retina to identify dysregulated genes and pathways.
Nicholas Owen, M Toms, Y Tian, L Toualbi, R Richardson, R Young, D Tracey-White, P Dhami, S Beck, M Moosajee
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Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina